miR-706 inhibits the oxidative stress-induced activation of PKCα/TAOK1 in liver fibrogenesis
نویسندگان
چکیده
منابع مشابه
miR-706 inhibits the oxidative stress-induced activation of PKCα/TAOK1 in liver fibrogenesis
Oxidative stress induces the activation of liver fibrogenic cells (myofibroblasts), thus promoting the expression of fibrosis-related genes, leading to hepatic fibrogenesis. MicroRNAs (miRNAs) are a new class of small RNAs ~18-25 nucleotides in length involved in post-transcriptional regulation of gene expression. Wound-healing and remodeling processes in liver fibrosis have been associated wit...
متن کاملMiR-200a/ZEB1 Pathway in Liver Fibrogenesis of Biliary Atresia
Objective: Biliary atresia (BA) is characterized by progressive liver fibrosis. Epithelial-mesenchymal transition (EMT) has been implicated as a key mechanism in the pathogenesis of organ fibrosis. MiR-200a has been shown to repress EMT. We aim to explore the role of miR-200a in the fibrogenesis of BA. Methods: We obtained the plasma samples and liver samples from patients with BA or controls t...
متن کاملThe protective effects of Curcuma longa extract on oxidative stress markers in the liver induced by Adriamycin in rat
Introduction: The aim of the study was to investigate the effects of Curcuma longa (C. longa) extract on Adriamycin-induced hepatotoxicity in rat. Methods: Animals were divided in six groups: Control (CO), Adriamycin (ADR), Adriamycin with Vitamin C (ADR+VitC), Vitamin C (Vit C), C. longa with Adriamycin (CL+ADR) and without Adriamycin (CL-ADR). Hepatotoxicity was induced by Adriamycin 5mg/kg ...
متن کاملEffect of Bioflavonoid Quercetin on Endotoxin-Induced Hepatotoxicity and Oxidative Stress in Rat Liver
Septicaemia caused by gram-negative pathogens is a dangerous infection which is associated with high incidence of liver dysfunction. The severe and acute hepatotoxicity is presumably due to massive release of endotoxin into systemic circulation after bacterial killing. The direct toxic effect of endotoxin is probably due to the increased production of reactive oxygen intermediates as O 2 - , p...
متن کاملAntioxidative Effects of Nano-curcumin on Liver Mitochondria Function in Paraquat-induced Oxidative Stress
Background: Paraquat (PQ), as the most widely used herbicide in agriculture, induces poisoning in humans and animals mainly through oxidative stress. This study aimed to investigate the protective effects of nano-curcumin compared with curcumin against PQ-induced mitochondrial dysfunction. Materials and Methods: Thirty-six Wistar rats were used in this study. They were separated into 6 groups...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep37509